18 datasets found

Analyzes thousands of genomic datasets to understand how transposable elements drive regulatory innovation. Nearly half of the human genome comprises these mobile sequences that...

Develops automated workflows extracting and standardizing proteomics metadata using bioinformatics and natural language processing. Enhances PRIDE repository accessibility for...

Analyzes structural, sequence, and gene-disease data linking protein entanglement to disease. Explores previously unrecognized causes of disease through protein topology-disease...

Analyzes omics datasets comparing cytokinesis under normal and high-temperature conditions across species. Identifies genetic factors enabling heat tolerance relevant to...

Develops multimodal AI integrating single-cell genomic data to reveal genome architecture-expression relationships. Identifies epigenetic drivers of neurodegeneration in...

Maps when topological entanglement (knots, slipknots, lasso motifs) emerged across protein families using sequence, structure, and phylogenetic data. Tests functional...

Synthesizes bacterial gene expression data to create the first atlas of cell states including growth, starvation, biofilm formation, and dormancy across diverse environments....

Integrates crosslinking mass spectrometry data from PRIDE with AlphaFold3 predictions to validate and map protein interactions. Delivers hybrid structural models integrated into...

Links evolutionary conservation with structural and functional signatures in intrinsically disordered regions. Integrates sequence alignments, molecular simulations, and...

Integrates multi-omics data from single-cell sequencing across well-characterized model cell lines. Creates a benchmarking resource for understanding regulatory mechanisms and...

Harmonizes fragmented protein turnover datasets across species (E. coli, yeast, mouse, human). Creates a standardized Protein Stability Database using consistent reanalysis...

Uses high-throughput mass spectrometry to investigate the prevalence and consequences of protein misfolding for protein homeostasis and aging-related structural changes across...

Investigates how protein instability and disorder shape network architecture across organisms, revealing connections between biophysical properties and network topology across...

Integrates high-resolution spatial transcriptomics and proteomics data to predict cellular fate. Develops computational frameworks for registering multi-modal spatial images,...

Examines intrinsically disordered region evolution in deep-sea organisms using metagenomic datasets and bioinformatics. Creates the first comprehensive map of molecular...

Resolves discrepancies between ribosomal translation detection and protein identification by synthesizing RNA-seq, ribosome profiling, and proteomics datasets. Quantifies...

Integrates simulations, deep mutational scanning, and evolutionary data to quantify dynamic coupling in proteins. Develops allosteric order parameters and trains models...

Computational tools and datasets for analyzing protein topological entanglement, supporting NCEMS working groups studying protein misfolding, disease phenotypes, and structural...